Manufacturer: Norbrook Laboratories Australia P/L
Registered Name Noromectin Pour-On for Cattle
Composition Ivermectin 5 mg/mL.
Actions Ivermectin paralyses and ultimately kills parasitic nematodes, arachnids and insects by a unique effect on the nervous system of these parasites. Ivermectin activates glutamate sensitive chloride ion channels in invertebrate muscle and nerve cells it also affects the release and binding of ?-aminobutyric acid (GABA), which opens chloride channels in nerves. The chloride channels are open when they should be closed and signals are not received by the end cell. The process is irreversible and leads to paralysis and death of the parasite.
Mammals do not have glutamate mediated chloride channels, and GABA mediated nerves occur only in the central nervous system, whereas in the invertebrate such nerves regulate the peripheral muscles. Ivermectin does not readily cross the blood brain barrier, with no notable effect on mammalian GABA binding. Therefore ivermectin has a wide margin of safety in mammals.
Indications Treatment and control of gastrointestinal nematodes Ostertagia ostertagi, Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, Oesophagostomum radiatum, Oe. venulosum, Strongyloides papillosus, Trichuris sp. and Nematodirus sp.; lungworms (Dictyocaulus viviparus); sucking and biting lice Linognathus vituli, Haematopinus eurysternus, Bovicola bovis and Solenopotes capillatus; chorioptic and sarcoptic mange mites; buffalo flies (Haematobia irritans exigua); and cattle ticks (Boophilus microplus).
Can effectively control infections with Ostertagia sp. (small brown stomach worms) acquired up to 14 days after treatment, Dictyocaulus viviparus (lungworm) acquired up to 28 days after treatment and Haematobia irritans exigua (buffalo fly) for up to 21 days after treatment.
Precautions Treatment must not be repeated in less than 42 days.
Not be used for any purpose, or in any manner, contrary to the label unless authorised under appropriate legislation.
This product is for application to the skin surface only, do not give orally or parenterally. Do not use in species other than cattle. Only use is a well ventilated area or outdoors. Cattle should not be treated when hair or hide is wet since reduced efficacy may be experienced. Rain falling on cattle in less than two hours after dosing may result in reduced efficacy. Reduced efficacy will result if applied to areas of the skin with mange scabs or lesions, or with dermatoses or adherent materials e.g. caked mud or manure.
Safety directions Gives off highly flammable vapour. Keep away from heat, sparks, open flame and other sources of ignition. Keep closed when not in use.
Poisonous if swallowed. Avoid contact with eyes, skin and clothing.
First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.
Disposal Triple or pressure rinse containers. Do not dispose of undiluted chemicals on site. Break, crush or puncture and bury empty containers in a local authority landfill. If no landfill is available bury the containers below 500 mm in a disposal pit specifically marked and set up for this purpose, clear of waterways, vegetation and roots. Empty containers should not be burnt. Protection of fish, crustaceans, and the environment. Do not contaminate dams, rivers or streams. Studies indicate that ivermectin binds readily and tightly to the soil and becomes inactive over time. Free ivermectin may adversely affect fish and certain water borne organisms.
Withholding Periods Meat 42 days.
Milk Nil.
Export Slaughter Interval 42 days.
Dosage and Administration Apply along the topline in a narrow strip extending from the withers to the tailhead. The dose rate is 1 mL/10 kg liveweight.
Cattle 50 to 100 kg liveweight. 10 mL. 101 to 150 kg. 15 mL. 151 to 200 kg. 20 mL. 201 to 250 kg. 25 mL. 251 to 300 kg. 30 mL. 301 to 350 kg. 35 mL. 351 to 400 kg. 40 mL. 401 to 450 kg. 45 mL. 450 to 500 kg. 50 mL. 501 to 550 kg. 55 mL. 551 to 600 kg. 60 mL. 601 to 650 kg. 65 mL.
Heavier animals, for example mature bulls, should receive an additional 5 mL for each 50 kg over 650 kg. A representative sample of animals should be weighed before treatment either with scales or a weighband. Dose rate should be based on the heaviest cattle in each group. Do not underdose. When there is large variation in size within the group, draft into two or more lines based on bodyweight to avoid excessive overdosing.
General instructions. The colour of Noromectin Pour-On fades when exposed to light and depending on the light intensity, fading may occur in less than 30 minutes. This rapid loss of colour does not reflect loss of potency of ivermectin. However, prolonged exposure to light can also result in a gradual decline of ivermectin potency in the formulation.
