Composition Bismuth salicylate 17.5 mg/mL; bentonite. Actions Antidiarrhoeal. The insoluble salt is converted to bismuth carbonate and sodium salicylate after oral administration. It lines the mucosal surface, adsorbs toxic compounds and has protective, antacid and antiseptic properties; it is mildly astringent. Peptosyl is nonantibiotic; it will not cause bacterial resistance to develop. It is nontoxic in animals and humans, displays antibacterial activity, decreases water loss, and may also help reduce the pain of inflammatory bowel diseases. Bismuth salicylate and other bismuth salts have been shown to inhibit plaque formation of enteric rotavirus in vitro. The salicylate component has an antiprostaglandin synthetase effect which may enhance its action in controlling acute secretory diarrhoea. Bentonite is a natural clay earth with properties similar to activated charcoal, and the ability to bind bacterial endotoxin. Indications Gastroenteritis and diarrhoea in dogs and horses. Warnings Safety in pregnant animals has not been established. Faecal colour may appear darker and be misinterpreted as melaena. Precautions If the condition does not resolve with appropriate symptomatic therapy, further diagnostic evaluation should be considered. Withholding Periods Meat. Horses: 28 days. Racing. If used in performance animals, the regulations of the relevant authorities regarding medication should be observed. Dosage and Administration Horses. 0.5 to 1 mL/kg bodyweight orally. Dogs. 0.25 to 0.5 mL/kg bodyweight orally. Repeat dose every 6 hours for 36 hours, and then at 12 hour intervals for a further 2 to 3 days.
