Manufacturer: Mavlab Pty Ltd Registered Name Fido's Closasole 10 kg Broadspectrum Wormer for Dogs & Cats Composition Levamisole (as hydrochloride) 42.2 mg, niclosamide 1,000 mg. Actions The mechanism of action of niclosamide appears to be by the uncoupling of oxidative phosphorylation of the cellular electron transport system and by inhibition of ATP synthesis in the parasitic worm. Levamisole acts as a cholinergic agonist and paralyses the worm allowing its expulsion, however, there is evidence of more than one mode of action. Niclosamide is poorly absorbed from the gut. Levamisole is absorbed from the gut and is metabolised by the liver. Indications Roundworm (Toxocara and Toxascaris sp.), hookworm (Uncinaria and Ancylostoma sp.), and tapeworm (Dipylidium and Taenia sp.) in dogs and cats. Contraindications Known sensitivity to levamisole or niclosamide. Precautions Discontinue use if unsteady gait or depressed appetite occurs after administration. Use with caution in debilitated animals and animals with reduced hepatic function. To prevent vomiting, administer with food and divide the dose. First aid. If poisoning occurs, contact a doctor or a Poisons Information Centre. Phone Australia 131 126. Disposal. Dispose of empty container by wrapping and placing in garbage. Dosage and Administration Administer with a light meal or crushed in food. Adult dogs and cats. 1 tablet/10 kg bodyweight once. Repeat every three months if necessary throughout life. Bitches and queens. 1 tablet/10 kg bodyweight, two treatments at an interval of 14 days during gestation and lactation.
